3. National Mississippi Museum and Aquarium
Located in Dubuque, Iowa, the National Mississippi Museum and Aquarium boasts two riverfront campuses that are popular attractions on the river. As an affiliate of the Smithsonian Institute, this impressive museum is known for its regional artifacts, hands-on exhibits and 4D theater. The aquarium is home to amazing exhibits that feature otters, rays and giant catfish. All ages will learn and be entertained at this venue that showcases the ecosystem of this vital waterway.